microRNA replacement therapy

microRNAs are tiny molecules that are encoded in the DNA within our cells. They are responsible for controlling expression of genes that dictate how the cell behaves, including deciding when to divide or move. In some cancers the amount of these microRNAs becomes altered, meaning the cells lose the break on expression of genes that cause cancer (oncogenes).

miReven is developing a drug, mRx-7, that mimics a specific microRNA called miR-7. By replacing this naturally occurring molecule, miR-7, which puts the brake on cancer cell proliferation, it will slow down the growth and spread (metastasis) of cancer cells with minimal side effects to non-cancerous cells. This will lead to increased survival and improved outcomes.